Zerumbone reduces TLR2 stimulation-induced M1 macrophage polarization pattern via upregulation of Nrf-2 expression in murine macrophages.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"The authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia, for funding this research work through the project number ISP23-121 Marwa Qadri: Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing. Zenat Khired: Conceptualization, Formal analysis, Writing – review & editing. Reem Alaqi: Methodology, Writing – review & editing. Sandy Elsayed: Writing – review & editing. Abdulaziz Alarifi: Writing – review & editing. Rayan Ahmed: Writing – review & editing. Hussain Alhamami: Writing – review & editing. Amani Khardali: Writing – review & editing. Walaa Hakami: Writing – review & editing."