Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment.

"these data were compared to public raw data available for healthy donor tfh naive memory regulatory and stem cell memory cd4 + t cells downloaded from geo datasets gse61697 gse65010 gse66384 and gse71566.; affymetrix data generated by us is available from gene expression omnibus (geo) (gse232609 confidential token for access: gnsjgkyozjulnmn)."

"Declarations Ethics approval and consent to participateAll mouse experimental procedures were carried out in compliance with protocols approved by the local ethical and experimentation committee (SBEA, Nice, France, autorisation N° 28790–2020121715244498 and B0608820).All human blood and tissues were obtained after informed consent and approval was obtained by the ethical commission of the hospitals according to the Helsinki declaration. Consent for publicationNot applicable. Competing interestsThe authors declare no conflict of interest. Competing interests The authors declare no conflict of interest."

"Funding This work was supported by the ‘Fondation ARC pour la Recherche sur le Cancer’, la Ligue Nationale Contre le Cancer “Equipe Labellisée”, the Agence Nationale de la Recherche’ (Labex SIGNALIFE ANR-11-LABX-0028–01), IDEX UCAJedi ANR-15-IDEX- 01 by ANR ANR-16-CE16-0024–01, la Ville de Nice, the Canceropôle PACA, Institut National du Cancer (INCA) and Conseil General des AM et la région PACA et Corse, the French Ministry of Research, la Fondation pour la Recherche Médicale (FRM) and la Societé Française d’Hématologie (SFH). AK was supported by a PhD fellowship from the French Ministry of Research. We also acknowledge ANR and Inserm Transfert for the ANR JCJC-20-CE14-0028–01 and CoPoC MAT-PI-17493-A-04 grants to R.J.A."