Acellular embryoid body and hydroxybutyl chitosan composite hydrogels promote M2 macrophage polarization and accelerate diabetic cutaneous wound healing.

"fig s4 data availability data will be made available on request. data availability data will be made available on request. acknowledgements this research was supported by the (program no 2024jc-ybms-149 and 2023-jc-qn-0886"

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This research was supported by the 10.13039/501100017596Natural Science Basic Research Program of Shaanxi (Program No. 2024JC-YBMS-149 and 2023-JC-QN-0886), 10.13039/100019903Beijing Science and Technology Innovation Medical Development Foundation (No. KC2023-JX-0186-PM018), and Incubation Project for the National Natural Science Foundation of Tumor Hospital of Shaanxi Province (No. SC23B02, SC221107, and SC211710). We thank Shaanxi Provincial Cancer Hospital Translational Medicine Center for the technical and equipment support. Yue Zhang: Project administration, Writing – original draft. Zheng-Hong Chen: Data curation, Investigation. Kun Zhao: Supervision. Yu-Dong Mu: Visualization. Kun-Long Li: Validation. Zhi-Min Yuan: Investigation. Zhi-Gang Liu: Software. Le Han: Writing – review & editing. Wei-Dong Lü: Funding acquisition, Project administration, Writing – original draft."