SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-20 data availability cryo-em maps for hepatitis b virus capsid (hbv core protein) and hepatitis b virus capsid in complex with sr protein kinase 2 were deposited in the electron microscopy data bank (emdb) under the access codes emd-37631 (full map apo form of hepatitis b virus capsid) emd-38062 (full map hepatitis b virus capsid in complex with sr protein kinase 2) and emd-37634 (local map sr protein kinase 2 bound at 2-fold vertex of hepatitis b virus capsid).; data availability cryo-em maps for hepatitis b virus capsid (hbv core protein) and hepatitis b virus capsid in complex with sr protein kinase 2 were deposited in the electron microscopy data bank (emdb) under the access codes emd-37631 (full map apo form of hepatitis b virus capsid) emd-38062 (full map hepatitis b virus capsid in complex with sr protein kinase 2) and emd-37634 (local map sr protein kinase 2 bound at 2-fold vertex of hepatitis b virus capsid)."

"The authors have declared that no competing interests exist."

"This work was supported by the General Research Fund (GRF) grants, 17126017 and 14177317, from the Hong Kong Research Grants Council (https://www.ugc.edu.hk/eng/rgc/) to C.P.C. and J.C.K.N., respectively; the Collaborative Research Fund (CRF) grants C4012-16E and C4033-19E from the Hong Kong Research Grants Council to J.C.K.N.; the Chinese University of Hong Kong Faculty of Science direct grant scheme (grant number 4053259), the Research Committee Group Research Scheme, and the State Key Laboratory of Agrobiotechnology ITC Fund to J.C.K.N. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."