DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.

"we found > 4000 differentially methylated regions (dmrs) that were either hypomethylated or hypermethylated in ad versus nd brains (fig 1 a; supplementary data 1 ).; additional file 3: supplementary data 1.; supplementary data 2."

"Declarations Ethics approval and consent to participateDe-identified human samples were obtained in agreement with the NIH NeuroBiobank or the Discovery Life Science Biobank. Written informed consent for participation was not required for this study in accordance with the national legislation and institutional requirements. The animal study was reviewed and approved by Animal Care and Use Committee (IACUC) of the Ohio State University College of Medicine. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Studies in the Amer Laboratory are supported by R01AI157205, R01AI159452, R01HL158747, Cystic Fibrosis Foundation CFF 810552-0621-01, NIH Covid supplement, and a Pilot Grant from the OSU Department of Microbial Infection and Immunity. Studies in the Ghoneim laboratory were supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R01AI170926. A. B. is supported in part by the C3 training grant. Images presented in this report were generated using the instruments and services at the Genomics Shared Resource, Campus Microscopy and Imaging Facility, The Ohio State University Comprehensive Cancer Center. This facility is supported in part by grant P30 CA016058, National Cancer Institute, Bethesda, MD, USA. We would also like to acknowledge the Rodent Behavior Core at the Ohio State University. This facility is supported in part by P30 core grant (NINDS P30NS04578). We would also like to acknowledge the Ohio State CCTS’s Clinical and Translational Science Award (CTSA) which supported this project by Award Number UM1TR004548 from the National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health."