Mannose-coupled AAV2: A second-generation AAV vector for increased retinal gene therapy efficiency.

"Declaration of interests M.M., D.D., and E.A. are inventors on a patent including the technology described in this manuscript. A.G., N.B., and G.M.L. are employees of Coave Therapeutics."

"The authors thank all personnel at the Boisbonne Center for Gene Therapy (ONIRIS, INSERM, Nantes, France) for handling and care of the rats and nonhuman primates included in this study. We also thank the vector core of TarGeT, UMR 1089 (CPV, INSERM and Nantes Université, http://umr1089.univ-nantes.fr) for the production of the rAAV vectors used in this study, and the staff at the Preclinical Analytics Core of TarGeT, UMR 1089 (PAC, INSERM, and Nantes Université) for the molecular analyses performed in this study. Thanks also to the IBISA MicroPICell facility (Biogenouest), a member of the France-Bioimaging national infrastructure supported by the French national research agency (ANR-10-INBS-04). Analysis and purification of chemical compounds were performed at the Chromatography Platform, CEISAM Laboratory, UMR 6230 CNRS/UN, Nantes Université. Thanks to Nicolas Ferry for reviewing the manuscript and to Owen Howard PhD for English language editing. This research was supported by the Fondation d’Entreprise Thérapie Génique en Pays de Loire, the Center Hospitalier Universitaire (10.13039/501100015613CHU) of Nantes, the Institut National de la Santé et de la Recherche Médicale (INSERM), and Nantes Université, by a grant from the 10.13039/501100001665French National Agency for Research (“Investissements d’Avenir” Equipex ArronaxPlus no. ANR-11-EQPX-0004) and by Coave Therapeutics (formerly Horama). Author contributionsFunding acquisition, M.M., P.M., E.A., D.D., and O.A.; supervision, M.M., V.P., J.-B.D., S.G.G., C.I., T.C., C.L.G., P.M., E.A., and O.A.; validation, M.M., V.P., M.B., D.A.-D., P.-A.L., N.P., M.A., A.M., E.L., J.-B.D., E.T., A.G., G.M.L., G.L.M., C.L.G., and D.D.; writing – original draft, M.M., V.P., A.G., N.B., G.M.L., S.G.G., G.L.M., T.C., C.L.G., P.M., E.A., D.D., and O.A.; writing – review & editing, M.M., V.P., G.M.L., C.L.G., P.M., E.A., D.D., and O.A.; conceptualization, M.B., J.-B.D., A.G., N.B., G.M.L., T.C., M.W., and D.D.; methodology, M.B., D.A.-D., P.A.L., N.P., M.A., A.M., E.L., E.T., A.G., G.L.M., T.C., M.W., and D.D.; visualization, J.-.B.D.; project administration, P.M., E.A., and O.A.; resources, P.M., E.A., D.D., and O.A."