Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification.

"significance was accepted at * #p < 0 05 ** ##p < 0 01 *** ###p < 0 005 and **** ####p < 0 0001 3 the sequencing data have been deposited into ncbi sequence read archive (sra) database under accession number prjna881493."

"Declaration of competing interest The authors declare no conflict of interest."

"The authors wish to express their gratitude to the financial supports from the 10.13039/501100001809National Natural Science Foundation of China (No.31971264), 10.13039/501100001809National Natural Science Foundation of China for Innovative Research Groups (No.51621002), Frontiers Science Center for Materiobiology and Dynamic Chemistry (No. JKVD1211002), and China Postdoctoral Science Foundation (2020M681320). Lili Sun: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – original draft, Writing – review & editing. Haoyi Niu: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software. Yuqiong Wu: Data curation, Investigation, Methodology, Software. Shiyan Dong: Data curation, Formal analysis, Investigation, Methodology. Xuefeng Li: Data curation, Investigation, Methodology. Betty Y.S. Kim: Investigation, Methodology, Resources. Changsheng Liu: Funding acquisition, Project administration, Supervision. Yifan Ma: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing. Wen Jiang: Conceptualization, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing. Yuan Yuan: Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing."