Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"AcknowledgementThis study was supported in part by start-up funding from UTHSC, intramural grants from the Helmholtz-Association (Program Infection and Immunity), and NIAID Research Grants 2-U19-AI100625–06 REVISED and 5U19AI100625–07 awarded to KS. K.R.S. is supported by NHMRC investigator grant 2007919. Z.A.L. is a UTHSC Summer Research Scholar. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Zhuoyuan Alex Li: Investigation, Formal analysis, Writing – original draft, Visualization, Funding acquisition. Akhilesh Kumar Bajpai: Software, Formal analysis, Data curation, Writing – original draft. Ruixue Wang: Validation, Investigation. Yaxin Liu: Validation, Investigation. Richard J. Webby: Resources. Esther Wilk: Investigation. Weikuan Gu: Supervision. Klaus Schughart: Methodology, Data curation, Writing – review & editing, Funding acquisition. Kui Li: Conceptualization, Methodology, Validation, Formal analysis, Resources, Writing – review & editing, Supervision, Project administration. Lu Lu: Conceptualization, Methodology, Formal analysis, Data curation, Resources, Writing – review & editing, Supervision, Project administration."