IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts.

"Declarations Ethics approval and consent to participateThe usage of PDAC patient tissue blocks from the Antwerp Biobank (Antwerp, Belgium; ID: BE71030031000) was approved by the Ethics Committee of the Antwerp University Hospital-University of Antwerp under study reference EC14/47/480 and EC13/47/469. The generation of patient-derived organoids from PDAC patients was carried out after written consent and approved by the Ethics Committee of the Antwerp University Hospital-University of Antwerp under study reference EC14/47/480. Buffy coats from four healthy donors were provided by the Red Cross Flanders and usage was approved by the UZA-UAntwerp Ethics Committee under study reference EC5488. All animal procedures were conducted in accordance with, and approval of, the Animal Ethics Committee of the UAntwerp under registration number 2021-55. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research project has been funded by Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society. L.G. and J.V.A. were supported by BOF grant FFB210425 of the University of Antwerp. T.V. (grant G040120N), D.Q. (grant 1S76421N), G.R. (grant 1S72821N), M.L.C. (grant 1S27021N) and D.C.D. (grant G053518N) were supported by Research Foundation Flanders (FWO). G.R. was supported by the public utility foundation MeToYou (Belgium). We would like to thank several patrons, as part of this research was funded by donations from different donors, including Dedert Schilde vzw, Mr. Willy Floren and the Vereycken family."