CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease.

"the single-nucleus gene counts and metadata available from cain et al [ ] on synapse (id: syn16780177) were converted into a seurat object [ ] in r studio for further processing."

"Competing interests The authors declare no competing interests."

"This work was supported by the Canadian Institutes of Health Research (CIHR; PJT-153101, EKL and JM; MOP89825, EKL; NGN-171423, ST; PJT-428404, DF), Krembil Foundation (DF, ST), Koerner Family Foundation (DF), CAMH Discovery Fund (DF, ST), Kavli Foundation (ST), McLaughlin Foundation (ST), Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-05834 and DGECR-2020-00048; ST). JM is supported by the Canadian Research Chairs program, as a Tier 1 Chair. ROS/MAP is supported by P30AG10161, P30AG72975, R01AG15819, R01AG17917. U01AG46152, U01AG61356. Author contributions: Conceptualization: JR, ST, DF, EKL; Method development: TH, PDJ, JAS, YW, DAB, ST, DF; Resources: TH, PDJ, JAS, YW, DAB; Data organization and cleaning: JR, YC, MM, EST. Data analysis: JR, YC, EST, ST, DF, EKL; Visualization: JR, ST, DF, EKL. Funding: ST, DF, EKL. Supervision: JM, ST, DF, EKL. Writing—Original Draft: JR, ST, DF, EKL. Writing - review and editing: All authors were involved in the review and editing of the final manuscript."