Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This study was supported by the 10.13039/501100004608Natural Science Foundation of Jiangsu Province (BK20220046); the 10.13039/501100001809National Natural Science Foundation of China (82072410); Changzhou's Leading Talent Program of Changzhou Science and Technology Bureau (CQ20210121); Key Laboratory of Orthopaedics of Suzhou (SZS2022017); the 10.13039/501100012246Priority Academic Program Development of Jiangsu Higher Education Institutions (10.13039/501100012246PAPD). Lei Deng: Writing – original draft, Formal analysis, Data curation, Conceptualization. Mingzhuang Hou: Writing – original draft, Formal analysis, Data curation, Conceptualization. Nanning Lv: Writing – original draft, Formal analysis, Data curation. Quan Zhou: Writing – review & editing, Formal analysis, Data curation. Xi Hua: Writing – review & editing, Data curation. Xiayu Hu: Writing – review & editing, Data curation. Xiaoyang Ge: Writing – review & editing, Data curation. Xuesong Zhu: Writing – review & editing, Methodology. Yong Xu: Writing – review & editing, Methodology. Huilin Yang: Writing – review & editing, Methodology, Funding acquisition. Xi Chen: Writing – review & editing, Supervision, Investigation, Funding acquisition. Hao Liu: Writing – review & editing, Writing – original draft, Supervision, Methodology, Investigation, Conceptualization. Fan He: Writing – review & editing, Writing – original draft, Supervision, Resources, Project administration, Methodology, Investigation, Formal analysis, Conceptualization."