Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer.

"Competing interests: ST, YT, and Y-TL have nothing to disclose. SKoy has received research funding from Otsuka Pharmaceutical, Shionogi Pharmaceutical and Chugai Pharmaceutical outside the submitted work. SF has nothing to disclose. HH has received honoraria from Bayer, Bristol-Myers Squibb, Chugai, Daiichi-Sankyo, Kyowa Hakko Kirin, Lilly, Merck Biopharma, MSD, Ono, Taiho, Takeda, and Yakult; fees for consulting or advisory roles for Bristol-Myers Squibb, Boehringer Ingelheim and Daiichi-Sankyo; and research grants from ALX Oncology, Amgen, Astellas, AstraZeneca, Bayer, BeiGene, Boehringer Ingelheim, Bristol-Myers Squibb, Chugai, Daiichi-Sankyo, Eisai, Janssen, Merck Biopharma, MSD, Ono Pharmaceutical, and Taiho Pharmaceutical outside the submitted work. YN has received honoraria from Chugai, Merck, and Guardant Health AMEA and research grants from Taiho, Chugai, Guardant Health, Genomedia, Daiichi-Sankyo, Seagen, and Roche Diagnostics outside the submitted work. YK has nothing to disclose. DK has received personal fees for advisory roles from Takeda and Eisai; honoraria from MSD, Pfizer, Chugai, Merck biopharma, Lilly, Sysmex, Nipponkayaku, Bristol-Myers Squibb, Ono Pharmaceutical, Taiho Pharmaceutical, Takeda, Eisai, and Daiichi-Sankyo; and research funding from Ono Pharmaceutical, MSD, Novartis, Sanofi, Janssen, Pierre Fabre Medicament, Isofol Medical AB, Hutchison MediPharma Limited, and Nippon Servier outside the submitted work. TKo has received honoraria from MSD, Bristol-Myers Squibb and Ono Pharmaceutical; personal fees for advisory roles from Boehringer Ingelheim, Kyowa Kirin and Taiho Pharmaceutical; and research funding from AstraZeneca, BeiGene, MSD, Amgen, Chugai Pharmaceutical, Taiho Pharmaceutical, Shionogi Pharma, and Amgen Astellas BioPharma outside the submitted work. HB has received honoraria from Ono Pharmaceutical, Taiho Pharmaceutical, and Eli Lilly Japan and research funding from Ono Pharmaceutical outside the submitted work. SM, TU, SKoj, MW, NS, and MK have nothing to disclose. TKu has received honoraria from AstraZeneca, Astellas Pharma, Ono Pharmaceutical, Bristol-Myers Squibb Japan, Daiichi-Sankyo, and Roche Diagnostics; personal fees for consulting or advisory roles from Astellas Pharma; and research funding from Daiichi-Sankyo and Roche Diagnostics outside the submitted work. TY has received research grants from Taiho, Ono, Chugai, Amgen, MSD, Daiichi-Sankyo, Eisai, FALCO biosystems, Genomedia, Molecular Health, Nippon Boehringer Ingelheim, Pfizer, Roche Diagnostics, Sysmex, and Sanofi outside the submitted work and honoraria from Bayer, Chugai, Merck Biopharma, MSD, Ono, and Takeda. HN has received research funding and honoraria from Ono Pharmaceutical, MSD, Bristol-Myers Squibb, and Chugai Pharmaceutical and research funding from Taiho Pharmaceutical, Daiichi-Sankyo, Kyowa Kirin, Zenyaku Kogyo, Oncolys BioPharma, Debiopharma, Asahi-Kasei, Sysmex, Fujifilm, SRL, Astellas Pharmaceutical, Sumitomo Dainippon Pharma, and BD Japan outside the submitted work. HM has nothing to disclose. IE has received research grants from Taiho Pharmaceutical and Ono Pharmaceutical outside the submitted work. AK has received personal fees for advisory roles from Roche and Lilly; honoraria from Roche, Merck Biopharma, Lilly, Bristol-Myers Squibb, Ono Pharmaceutical, Taiho Pharmaceutical, and Daiichi-Sankyo; and research funding from Ono Pharmaceutical, MSD, Sanofi, AstraZeneca, and Eisai outside the submitted work."

"Funding: EPOC1603 was supported by Bayer HealthCare Pharmaceuticals and Ono Pharmaceuticals. EPOC1704 was supported by Taiho Pharmaceutical and Ono Pharmaceuticals. The funding bodies had no role in the study design; data collection, analysis, or interpretation; or in the writing of the report."