Disrupted pattern of rich-club organization in structural brain network from prediabetes to diabetes: A population-based study.

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"CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest."

"FUNDING INFORMATION This research received support from National Natural Science Foundation of China (82271329), National Key R&D Program of China (2016YFC0901002), Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2019‐I2M‐5‐029), Key Science & Technologies R&D Program of Lishui City (2019ZDYF18), Zhejiang provincial program for the Cultivation of High‐level Innovative Health talents, Beijing Natural Science Foundation (Grant No. Z200016)."

"The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study is an ongoing, population‐based, prospective cohort study. The target population comprised community‐dwelling adults (aged 50–75 years), based on cluster sampling from six villages and four communities in Lishui city in China. The rationale and methodology have been described previously (Pan et al., ). The present report used cross‐sectional data from the PRECISE study (Wave 1), including 3067 participants who completed the baseline assessment between May 2017 and September 2019. MRI measurements were available for 2376 of the 3067 participants (643 participants did not have DTI data available, and 48 participants had poor quality scans). We also excluded 156 participants due to severe head‐motion (n = 118) or incomplete MRI data (n = 38). Two participants were missing FPG, 2‐h post‐load glucose, and glycated hemoglobin (HbA1c) data. Thus, 2218 participants were included in this study (Figure ). The PRECISE study was approved by the ethics committee at Beijing Tiantan Hospital (IRB approval number: KY2017‐010‐01) and the ethics committee at Lishui Hospital (IRB approval number: 2016‐42). All participants provided written informed consent before entering this study. The trial registration number was ClinicalTrials.gov Registry (NCT03178448)."