Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study.

"Declarations Ethical approval and consent to participateThe study protocol was approved by the Local Ethics Committee (Comitato Etico Regione Marche—CERM) and it conformed to the principles of Helsinki declaration. NCT02750163, trial registered on the 25/04/2016. In compliance with national applicable laws, informed consent was obtained from the subjects before inclusion; patients that were temporarily unable to consent for neurological impairment or sedation were included in the study with deferred subject consent and written informative for the next of kin at the time of enrollment (these patients did not belong to groups of vulnerable population). Consent for publicationI confirm that the manuscript has been read and approved for submission by all the named authors. Competing interestsThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Competing interests The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Funding Università Politecnica delle Marche."

"Declarations: Ethical approval and consent to participateThe study protocol was approved by the Local Ethics Committee (Comitato Etico Regione Marche—CERM) and it conformed to the principles of Helsinki declaration. NCT02750163, trial registered on the 25/04/2016. In compliance with national applicable laws, informed consent was obtained from the subjects before inclusion; patients that were temporarily unable to consent for neurological impairment or sedation were included in the study with deferred subject consent and written informative for the next of kin at the time of enrollment (these patients did not belong to groups of vulnerable population).: Consent for publicationI confirm that the manuscript has been read and approved for submission by all the named authors.: Competing interestsThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Ethical approval and consent to participate: The study protocol was approved by the Local Ethics Committee (Comitato Etico Regione Marche—CERM) and it conformed to the principles of Helsinki declaration. NCT02750163, trial registered on the 25/04/2016. In compliance with national applicable laws, informed consent was obtained from the subjects before inclusion; patients that were temporarily unable to consent for neurological impairment or sedation were included in the study with deferred subject consent and written informative for the next of kin at the time of enrollment (these patients did not belong to groups of vulnerable population)."