Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults.

"Declarations Conflict of interestAuthor Bowen Li is employed by the LipidALL Technologies Company Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Ethics approvalWe declare that this study complied with the Declaration of Helsinki and got the approval of the ethics committee of Xuanwu Hospital, Capital Medical University, Beijing, China. Informed consentAll participants signed the informed consent following the Declaration of Helsinki and the study was approved by the ethical review board of Xuanwu Hospital Capital Medical University. Conflict of interest Author Bowen Li is employed by the LipidALL Technologies Company Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Funding This work was supported by the National Key R&D Program of China (2020YFC2008606 and 2020YFC2008604) and National Natural Science Foundation of Beijing (7202059)."