High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures.

"the rna sequencing data files have been deposited in the gene expression omnibus (geo) database under the accession code gse240547."

"Declarations Ethics approval and consent to participateThe animal and human studies were approved by the the Institutional Review Board of the Center for Reproductive Medicine, Shandong University (Approval Number: IRB 2022-56). Prior to inclusion in this study, all participants provided written informed consent. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National Key Research and Development Program of China (2022YFC2703502, 2021YFC2700400), the Basic Science Center Program (31988101), National Natural Science Foundation of China (82371644, 82100839), Shandong Provincial Key Research and Development Program (2020ZLYS02), Taishan Scholars Program of Shandong Province (ts20190988, tsqn202312387), CAMS Innovation Fund for Medical Sciences (2021-I2M-5-001), Shandong Provincial Natural Science Foundation (ZR2020QH083), and the Fundamental Research Funds of Shandong University (2023KJ021, 2023QNTD004)."