Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis.

"Declaration of competing interest Chi Chiu Wang is an active member of the World Endometriosis Society and an advisor of Aptorum Group, the licensee of ProEGCG. Chi Chiu Wang and Chi Chiu Wang are the inventor of ProEGCG for endometriosis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"This work was supported by the GRF RGC & CRF, Hong Kong (Grant Nos.: 475012 and C5045-20 EF); HMRF, Hong Kong (Grant No.: 03141386); ITF, Hong Kong (Grant No.: ITS/209/12); UGC Direct Grant 2011,2012, 2021.032; HKOG Trust Fund 2011, 2014, 2019; and the National Natural Science Foundation of China (Grant Nos.: 81974225 and 82201823). The Chemical proteomics core facility at Biomedicum (MBB, Karolinska Institute), also the Unit of SciLifeLab and part of the Swedish National Infrastructure for Biological Mass Spectrometry (BioMS), provided full support in the experimental design and the performance of the proteomics analysis using the Proteome Integral Solubility Alteration (PISA) assay for target discovery, with relative data analysis. Sze Wan Hung: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Data curation, Writing - Original draft preparation, Reviewing and Editing, Visualization; Massimiliano Gaetani: Conceptualization, Methodology, Software, Investigation, Resources, Data curation, Writing - Reviewing and Editing; Yiran Li: Methodology, Investigation, Validation; Zhouyurong Tan: Investigation, Validation; Gene Chi Wai Man: Methodology, Formal analysis, Investigation, Resources, Data curation, Writing - Reviewing and Editing; Zheng Xu: Investigation, Validation; Ruizhe Zhang: Investigation, Validation; Yang Ding: Investigation, Validation; Tao Zhang: Writing - Reviewing and Editing, Funding acquisition; Yi Song: Resources; Yao Wang: Writing - Reviewing and Editing; Jacqueline Pui Wah Chung: Resources, Writing - Reviewing and Editing; Tak Hang Chan: Resources, Writing - Reviewing and Editing; Roman A. Zubarev: Conceptualization, Resources, Writing - Reviewing and Editing, Supervision; Chi Chiu Wang: Conceptualization, Resources, Writing - Reviewing and Editing, Supervision, Funding acquisition"