Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This work here was in part supported by grants awarded by St David's 10.13039/100001236Medical Foundation, Registered Charity No. 1122688; the 10.13039/100015846Welsh Government in support of the C81844/C81845 ACCELERATE (Welsh Health Innovation Technology Accelerator) project. The results published here are part based upon data generated by The Cancer Genome Atlas (TCGA) Research Network: https://www.cancer.gov/tcga. EEV was supported by 10.13039/501100000289Cancer Research UK [grant number C18281/A29019]. NJ was supported by a New Investigator Research Grant from the Medical Research Council, United Kingdom [grant number MR/X000095/1]. M.R. Farook: Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing. Z. Croxford: Data curation, Formal analysis, Methodology. S. Morgan: Data curation. A.D. Horlock: Data curation, Methodology, Writing – review & editing. A. Holt: Data curation, Formal analysis. A. Rees: Data curation, Formal analysis. B.J. Jenkins: Data curation, Formal analysis. C. Tse: Data curation. E. Stanton: Data curation. D.M. Davies: Conceptualization. C.A. Thornton: Conceptualization. N. Jones: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing. I.M. Sheldon: Conceptualization, Writing – review & editing, Supervision. E.E. Vincent: Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing. J.G. Cronin: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing."