Tanreqing injection inhibits dengue virus encephalitis by suppressing the activation of NLRP3 inflammasome.

"Declarations Ethics approval and consent to participateAll animals were kept in a biosafety level-2 facility of the Animal Experimental Center of Guangzhou University of Chinese Medicine. Animal experiments were conducted at Animal Experimental Center of Guangzhou University of Chinese Medicine. The 3 R’s of ethics principles for animal experimentation was respected and fully considered during the experiments. All animal studies were carried out in compliance with the rules of the Ethics Committee of Guangzhou University of Chinese Medicine (Permit number: 20211026004). Additionally, virus infection experiments were conducted in a biosafety level 3 laboratory (BSL-3), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University according to biosafety regulations. Consent for publicationAll authors consent to publish this manuscript. Competing interestsThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"Funding The work was supported by the National Science Foundation of China (81730110), the Guangzhou Education Bureau University Scientific Research project (201831845), the Young Elite Scientists Sponsorship Program by CACM (2019-QNRC2-C14), and the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDHVPS2018)."