Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-28 data availability the nucleotide sequences that support the findings of this study are publicly available from genbank with the identifiers (lc637980 lc637981) https://www ncbi nlm nih gov/nuccore/lc637980 https://www ncbi nlm nih gov/nuccore/lc637981 .; data availability the nucleotide sequences that support the findings of this study are publicly available from genbank with the identifiers (lc637980 lc637981) https://www ncbi nlm nih gov/nuccore/lc637980 https://www ncbi nlm nih gov/nuccore/lc637981 .; the resulting plasmid pbrev71-sk-ev006 (sequence deposited as genbank accession no lc637980) is identical to the previously deposited sequence (genbank accession no ab469182) except for the two nucleotides at positions5250 and 5674. these cell lines were authenticated with geneprint 10 system (promega) [ ] by bex co ltd japan ( s1 data ).; m (tif) s1 table (pdf) s2 table (pdf) s3 table (pdf) s1 data (pdf) we thank jieyan pan for improvement of the ev-a71 binding assay lili zhang for detection of scarb2 in jurkat cells and keiko furuhata for assistance with cell sorting. data availability the nucleotide sequences that support the findings of this study are publicly available from genbank with the identifiers (lc637980"

"The authors have declared that no competing interests exist."

"This work was supported in part by JSPS KAKENHI (JP15K08512 and JP19K07585 to YN; JP16H05200 to HS) (https://www.jsps.go.jp/english/index.html), the AMED Research Program on Emerging and Re-emerging Infectious Diseases (JP18fk0108004, JP21fk0108084, and JP23fk0108627 to YN; JP21fk0108084 to HS) (https://www.amed.go.jp/en/index.html), the US NIH (R01AI072490 and R21AI111285 to JMB) (https://www.nih.gov/grants-funding), and the Plotkin Endowed Chair in Infectious Diseases at the Children’s Hospital of Philadelphia (CHOP) to JMB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."