Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.

"the cbm nucleotide sequence data were deposited at genbank https://www ncbi nlm nih gov/genbank/ with accession numbers or596380 through or596384 for strains106 220 322 363 and 422 respectively."

"Declaration of interests Authors declare that they have no competing interests."

"This study was supported by grants from the 10.13039/501100004359Swedish Research Council and from regional agreements between 10.13039/501100004885Umeå University and 10.13039/501100002960Västerbotten County Council (ALF and TUA); the TUA research funding formed by the 10.13039/501100005761Sahlgrenska Academy at the 10.13039/501100005760University of Gothenburg/region Västra Götaland; fund for Cutting-Edge Medical Research grant from the County Council of Västerbotten; the Swedish Dental Society; and local foundations at 10.13039/501100004885Umeå University. We acknowledge Prof. T. Borén and Assoc. Prof. A. Johansson and Assoc. Prof A. Esberg for support and thank the families and public health care and other personnel who participated in the study."