Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction.

"Declarations Ethics approval and consent to participateAll animal experiments were approved by the Research Center for Animal Life Science of Jinan Center Hospital and conducted following institutional ethics committee guidelines (Protocol number JNCH2021-128). The authors confirm that all experiments were performed in accordance with Chinese guidelines and regulations for scientific and ethical experimentation. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study was supported by the National Natural Science Foundation of China (82370725, 82371604, 82271622, 82071569, 82070756, 82102395, 82200049, and 82101639); the Shandong Provincial Natural Science Foundation (ZR2021QH083, ZR2021ZD35, ZR2022QH349, ZR2022QH374, and ZR2023QH316); the Shandong Province Medical and Health Development Plan(202304020860, and 202303111477); the Jinan Science and Technology Plan Project (202134046, 202019064, 202328033, and 202328037); the Jinan Municipal Health Commission Big Data Technology Program(2023-YBD-2-02); the Jinan Key Laboratory of Medical Sciences Foundation (20211201); the Jinan Talent Development Special Fund (2021GXRC018); the Evergreen Tree "Excellent Young and Middle-aged Doctors Training Project of Central Hospital Affiliated with Shandong First Medical University (GDRC2021002); Shandong provincial colleges and universities youth innovation technology support program (2023KJ181) and the Introduced Talents of Jinan Central Hospital (YJRC2021011)."