A novel complement C3 inhibitor CP40-KK protects against experimental pulmonary arterial hypertension via an inflammasome NLRP3 associated pathway.

Authors:
Dai L; Chen Y; Wu J; He Z; Zhang Y and 4 more

Journal:
J Transl Med

Publication Year: 2024

DOI:
10.1186/s12967-023-04741-z

PMCID:
PMC10870435

PMID:
38365806

Journal Information

Full Title: J Transl Med

Abbreviation: J Transl Med

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Medicine

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
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Evidence found in paper:

"Declarations Ethics approval and consent to participateThis study was performed in compliance with the Guide for the Care and Use of Laboratory Animals (NIH Publication No. 85–23, revised 1996), and all animal procedures and protocols were approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China). Approval Code: No: TJH-202306044. Consent for publicationNot applicable. Competing interestsThe remaining authors have nothing to disclose. Competing interests The remaining authors have nothing to disclose."

Evidence found in paper:

"Funding This work was supported by the National Natural Science Foundation of China (No. 81873523; No. 82070490) to HZ."

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Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025