HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.

"kjzd-k202212801) the key support object of amu (no 410301060133) to g h and the china urologic cancer research foundation (no 024) to j l data availability rna-seq data are deposited at gene expression omnibus (accession number: gse254851). data availability rna-seq data are deposited at gene expression omnibus (accession number: gse254851"

"Declarations Ethics approval and consent to participateThe study was approved by the Ethics Committee of Chongqing University Cancer Hospital (CZLS2023350-A) and performed by the Declaration of Helsinki for human subject protection. Animal-handling procedures were conducted in compliance with guidelines for the Care and Use of Laboratory Animals published by the NIH, and all animal experimental protocols were approved by the Animal Care and Use Committee of Army Medical University. Consent for publicationAll the patients were provided with written informed consent before enrolment. Competing interestsThe authors declare no potential competing interests. Competing interests The authors declare no potential competing interests."

"Funding This work was supported by the Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJZD-K202212801), the Key Support Object of AMU (No. 410301060133) to G. H., and the China Urologic Cancer Research Foundation (No. 024) to J.L."