The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer.

"availability of data and materials the tcga and geo database contain all the data produced and/or scrutinized during this research. the study's series in geo was identified as gse245440"

"Declarations Ethics approval and consent to participateThe Institutional Ethics Committee of Shandong First Medical University's Central Hospital gave its approval and review to this study. The Central Hospital Affiliated to Shandong First Medical University's Animal Care and authorized the evaluation and authorization of animal research conducted in this study. Details regarding the authorization can be found in Additional file 1: Figure S3-S4. Consent for publicationNot applicable. Competing interestsThe authors assert that the Figure legend belongs solely to them,and they declare that they have no competing interests. Competing interests The authors assert that the Figure legend belongs solely to them,and they declare that they have no competing interests."

"Funding This study was supported in part by grants from the following sources: National Natural Science Foundation of Shandong (Grant No: ZR2022QH332); National Natural Science Foundation of China (Grant No: 8220081418); Jinan Science and Technology Bureau's Clinical Technology Innovation Program. (Grant No: 202134058); Scientific Research Start-up Funds for talent introduction of Jinan Central Hospital (Grant No: YJRC2021010)."