Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins.

"Declarations Ethics approval and consent to participateAll patient samples were obtained with informed consent from the first Affiliated Hospital of Sun Yat-sen University. Sample collection was approved by the Hospital’s Protection of Human Subjects Committee. The mice were maintained under specific pathogen-free conditions in the Laboratory Animal Center of Sun Yat-sen University. All experimental procedures were performed according to the institutional ethical guidelines for animal experiments. Consent for publicationNot applicable for this article. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research was supported by Natural Science Foundation of Guangdong Province (No. 2021B1515020002), and China (Nos. 32170570, 32370594 and 32270598), and National Key R&D Program of China (Nos. 2022YFA1300020 and 2021YFA1300502), and Natural Science Foundation of Guangdong Province (No. 2022A1515140018) and Guangzhou (No. 2024A04J5004), and the Fundamental Research Funds for the Central Universities, Sun Yat-sen University (No. 231gbj010)."