Hepatitis E outbreak in the health district of Bocaranga-Koui, Central African Republic, 2018-2019.

"the sequences obtained in this study were deposited in genbank with accession numbers mn901844 to mn901869 and mw258967 to mw258978.; hev genotype 1e sequences obtained in the present study were deposited in the ncbi genbank database on the accession numbers mn901844 to mn901869 and mw258967 to mw258978.; the sequences obtained in this study were deposited in genbank with accession numbers mn901844 to mn901869 and mw258967 to mw258978. availability of data and materials all data generated or analyzed during this study are included in this published article. the sequences obtained in this study were deposited in genbank with accession numbers mn901844"

"Declarations Ethics approval and consent to participateThe research was approved by the Ethics and Scientific Committee of the Faculty of Health Sciences, University of Bangui, Central African Republic (decision number N°38/UB/FACSS/IPB/CES.023) and conducted within the guidelines of the Declaration of Helsinki. Because samples were taken as part of the national surveillance of yellow fever, and that the differential diagnosis of yellow fever is hepatitis E virus infection, the informed consent of the participants was not required.Written informed consent was waived by the « Comité Éthique et Scientifique/Faculté des Sciences, Université de Bangui/Institut Pasteur de Bangui (CES). Hence the CES gave authorization to publish the results from yellow fever national surveillance data used in the differential diagnosis of HEV infection without requiring informed consent. As the state of hepatitis E outbreak had been declared by the Ministry of Health and Population of the Central African Republic in this health district during this time, any person presenting conjunctival jaundice accompanied by a fever had to be systematically sampled for a HEV serological test, and symptomatic treatment was initiated if the serology (anti-HEV-IgM antibodies) of the HEV infection was positive. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding WHO grant number 2021/1098759–0."