The impact of using reinforcement learning to personalize communication on medication adherence: findings from the REINFORCE trial.

"data availability de-identified data necessary to reproduce results reported here are posted on the harvard dataverse an open access repository for research data at https://dataverse harvard edu/ .; code availability code necessary to reproduce results reported here are available in the harvard dataverse at https://dataverse harvard edu/ . data availability de-identified data necessary to reproduce results reported here are posted on the harvard dataverse"

"Competing interests At the time this study was conducted, E.Y.-T. was an employee of Microsoft. N.K.C. serves as a consultant to Veracity Healthcare Analytics and holds equity in RxAnte and DecipherHealth; unrelated to the current work, N.K.C. has also received unrestricted grant funding payable to Brigham and Women’s Hospital from Humana. N.H. has received personal fees from Cerebral unrelated to the current work. The remainder of the authors report no conflicts of interest."

"Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number P30AG064199 to BWH (N.K.C. PI). J.C.L. was supported by a career development grant (K01HL141538) from the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors wish to thank the Digital Care Transformation team at BWH, the team responsible for managing Microsoft Dynamics 365 SMS Texting."

"Ethical approval: The trial was approved by the institutional review board (IRB) of Mass General Brigham and registered with clinicaltrials.gov (NCT04473326). The authors were responsible for performing study analyses, writing the manuscript, substantive edits, and submitting final contents for publication. Patients were not blinded due to the nature of the interventions. No data monitoring committee was deemed necessary by the IRB."