Overexpression of VEGFα as a biomarker of endothelial dysfunction in aortic tissue of α-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry's disease.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision."

"The authors declare financial support was received for the research, authorship, and/or publication of this article.This study was supported by a research grant to MP from Takeda/Shire. The α-GAL-Tg/KO mice were kindly provided by Amicus Therapeutics. FB was supported by the Else Kröner-Fresenius-Stiftung and the German Society of Nephrology. FB was funded by the Federal Ministry of Education and Research under funding number 01EO2106. Responsibility for the content of this publication lies with the author. PK was partially supported by the European Union AFFECT-AF, MAESTRIA, British Heart Foundation, German Center for Cardiovascular Research (DZHK), German Research Foundation, and Leducq Foundation. Takeda/Shire was not involved in the study design, analysis, interpretation of data, the writing of this article or the decision to submit it for publication."