Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment.

"table 1 summary of six geo datasets involved in the exploration and validation cohort geo dataset experiment type treatment cohort samples gse51440 expression profiling array guselkumab exploration 20 nl; 22 bl; 9 w1; 8 w12 gse173706 scrna-seq -- exploration 11 pn; 14 pp gse201827 expression profiling array secukinumab validation 139 nl; 95 bl; 47 w12; 25 w40; 41 w52 gse137218 expression profiling array secukinumab validation 14 nl; 14 bl; 14 w1; 14 w2; 14 w12 gse102725 expression profiling array secukinumab validation 10 nl; 10 bl; 10 w16; 5 w32 gse178228 expression profiling array ixekizumab validation 32 bl; 30 w1; 26 w2; 29 w4 note : - the skin samples included in this dataset were not subjected to any form of treatment for psoriasis w1 w2 w4 w12 w16 w32 w40 w52 lesion samples collected at different time points after treatment. all data analysis parameters were set according to the official documentation available on github ( https://github com/sqjin/cellchat )."

"all data analysis parameters were set according to the official documentation available on github ( https://github com/sqjin/cellchat )."

"Disclosure The authors declare no competing interests related to this study."

"This research received no external funding."