Loss of symbiotic and increase of virulent bacteria through microbial networks in Lynch syndrome colon carcinogenesis.

"the data for this study have been deposited in the european nucleotide archive (ena) at embl-ebi under accession number prjeb70916 for shotgun metagenomic data ( https://www ebi ac uk/ena/browser/view/prjeb70916 ) and prjeb70919 for 16s rrna data ( https://www ebi ac uk/ena/browser/view/prjeb70919 )."

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The whole metagenomic pilot study was financially supported by Canceropole Ile de France as an emerging study in 2016. For gene analysis and system biology, it was partially supported by Grant 5 R01 CA264048-03. The Clinical Research Hospital Program provided financial support for the validation study AAS-Lynch (PHRC: project number PHRC-K13-117); PHRC (Program for Clinical Research at Hospital) under INCA (National Institute of Cancer in France)."