Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network.

"Declarations Ethics approval and consent to participateThe study protocol was approved by the institutional review boards and ethics committees of participating sites in adherence with the Declaration of Helsinki. Consent for publicationNot applicable. Competing interestsThe authors would like to disclose the following financial relationships: Izmirly, Peter Consultant: GSK, Momenta/Janssen; Kim, Mimi: None; Carlucci, Philip: none; Preisinger, Katherine: none; Zaminski, Devyn: none; Dall’Era, Maria: Consultant: GSK, Aurinia, AstraZeneca, Lilly, Biogen; Data Monitoring Committee: Janssen, Pfizer, Amgen; Kalunian, Kenneth: Advisor: AstraZeneca, RemeGen, BMS, Amgen, EquilliumBio, KezarBio, Aurinia, GSK, Roche/Genentech, Novarits, Horizon, Idorsia, Artivabio, Cabaletta, Merck, Alpine Immune Sciences, AbbVie, Vera Therapeutics, Aclaris Therapeutics, Gilead, Pfizer; Grants: Amgen, UCB, Acceleron, PreventionBio, Feinstein Institute, Alexion, NIH/MUSC, NIH/Immune Tolerance Network, Cugene, Kyowa Kirin, Daichi Sankyo; Fava, Andrea: none; Belmont, Michael: none; Wu, Ming: none; Putterman, Chaim: none; Anolik, Jennifer: Pending; Barnas, Jennifer: none; Diamond, Betty: Consultant: Nextcure, DBV, Alpine, iCell, Bayer, Magnolia, Kyverna, Nighthawk; Davidson, Anne: none; Wofsy, David: none; Kamen, Diane: Data safety and monitoring committee member: Alpine Immune Sciences; Data And Safety Monitoring Chair: Equillium; James, Judith: Advisor: GSK, Novartis; IP licensing and grant support: Progentec Biosciences; Guthridge, Joel: none; Apruzzese, William: Employment: Pfizer (began after this work concluded); Rao, Deepak: Consultant: GSK, AstraZeneca, Bristol-Myers Squibb, Pfizer; grant support unrelated to this work: Janssen, Bristol-Myers Squibb, Merck; Weisman, Michael: none; Petri, Michelle Consultant: Alexion, Amgen, AnaptysBio, Annexon Bio, Argenx, AstraZeneca, Axdev, Biogen, Boxer Capital, Cabaletto Bio, Caribou Biosciences Inc, CVS Health, Exo Therapeutics, Gilead Biosciences, GSK, Horizon Therapeutics, Idorsia Pharmaceuticals, Janssen, Kira Pharmaceuticals, Eli Lilly, MedShr, Momenta Pharmaceuticals, Nexstone Immunology, Nimbus Lakshmi, Proviant, Sanofi, Sinomab Biosciences, UCB; Invited speaker: Arthros-FocusMedEd, Aurinia; Data safety and monitoring board member: Emergent Biosolutions, IQVIA, Merck EMD Serono; grant support: Eli Lilly, Exagen, AstraZeneca, GSK, Thermofisher, Janssen, Aurinia; Buyon, Jill, Consultant: Bristol-Myers Squibb; GlaxoSmith Kline, Related Sciences, Ventus Therapeutics; Furie, Richard: Consultant: GSK, Genetech, Aurinia, Kezar. Competing interests The authors would like to disclose the following financial relationships: Izmirly, Peter Consultant: GSK, Momenta/Janssen; Kim, Mimi: None; Carlucci, Philip: none; Preisinger, Katherine: none; Zaminski, Devyn: none; Dall’Era, Maria: Consultant: GSK, Aurinia, AstraZeneca, Lilly, Biogen; Data Monitoring Committee: Janssen, Pfizer, Amgen; Kalunian, Kenneth: Advisor: AstraZeneca, RemeGen, BMS, Amgen, EquilliumBio, KezarBio, Aurinia, GSK, Roche/Genentech, Novarits, Horizon, Idorsia, Artivabio, Cabaletta, Merck, Alpine Immune Sciences, AbbVie, Vera Therapeutics, Aclaris Therapeutics, Gilead, Pfizer; Grants: Amgen, UCB, Acceleron, PreventionBio, Feinstein Institute, Alexion, NIH/MUSC, NIH/Immune Tolerance Network, Cugene, Kyowa Kirin, Daichi Sankyo; Fava, Andrea: none; Belmont, Michael: none; Wu, Ming: none; Putterman, Chaim: none; Anolik, Jennifer: Pending; Barnas, Jennifer: none; Diamond, Betty: Consultant: Nextcure, DBV, Alpine, iCell, Bayer, Magnolia, Kyverna, Nighthawk; Davidson, Anne: none; Wofsy, David: none; Kamen, Diane: Data safety and monitoring committee member: Alpine Immune Sciences; Data And Safety Monitoring Chair: Equillium; James, Judith: Advisor: GSK, Novartis; IP licensing and grant support: Progentec Biosciences; Guthridge, Joel: none; Apruzzese, William: Employment: Pfizer (began after this work concluded); Rao, Deepak: Consultant: GSK, AstraZeneca, Bristol-Myers Squibb, Pfizer; grant support unrelated to this work: Janssen, Bristol-Myers Squibb, Merck; Weisman, Michael: none; Petri, Michelle Consultant: Alexion, Amgen, AnaptysBio, Annexon Bio, Argenx, AstraZeneca, Axdev, Biogen, Boxer Capital, Cabaletto Bio, Caribou Biosciences Inc, CVS Health, Exo Therapeutics, Gilead Biosciences, GSK, Horizon Therapeutics, Idorsia Pharmaceuticals, Janssen, Kira Pharmaceuticals, Eli Lilly, MedShr, Momenta Pharmaceuticals, Nexstone Immunology, Nimbus Lakshmi, Proviant, Sanofi, Sinomab Biosciences, UCB; Invited speaker: Arthros-FocusMedEd, Aurinia; Data safety and monitoring board member: Emergent Biosolutions, IQVIA, Merck EMD Serono; grant support: Eli Lilly, Exagen, AstraZeneca, GSK, Thermofisher, Janssen, Aurinia; Buyon, Jill, Consultant: Bristol-Myers Squibb; GlaxoSmith Kline, Related Sciences, Ventus Therapeutics; Furie, Richard: Consultant: GSK, Genetech, Aurinia, Kezar."

"Funding This work was supported by the Accelerating Medicines Partnership (AMP) in Rheumatoid Arthritis and Lupus Network. AMP is a public–private partnership (AbbVie Inc., Arthritis Foundation, Bristol-Myers Squibb Company, Foundation for the National Institutes of Health, GlaxoSmithKline, Janssen Research and Development, LLC, Lupus Foundation of America, Lupus Research Alliance, Merck Sharp & Dohme Corp., National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Pfizer Inc., Rheumatology Research Foundation, Sanofi and Takeda Pharmaceuticals International, Inc.) created to develop new ways of identifying and validating promising biological targets for diagnostics and drug development. Funding was provided through grants from the National Institutes of Health (UH2-AR067676, UH2-AR067677, UH2-AR067679, UH2-AR067681, UH2-AR067685, UH2- AR067688, UH2-AR067689, UH2-AR067690, UH2-AR067691, UH2-AR067694, and UM2- AR067678)."