Multivalent cytomegalovirus glycoprotein B nucleoside modified mRNA vaccines did not demonstrate a greater antibody breadth.

"Competing interests S.R.P. serves as a consultant to Merck, Pfizer, Moderna, Dynavax, and Hoopika CMV vaccine programs and leads sponsored vaccine programs with Moderna and Merck. In accordance with the University of Pennsylvania policies and procedures and our ethical obligations as researchers, we report that D.W. and N.P. are named on patents that describe the use of nucleoside-modified mRNA as a platform to deliver therapeutic proteins and vaccines. We have disclosed those interests fully to the University of Pennsylvania, and we have in place an approved plan for managing any potential conflicts arising from the licensing of our patents. P.J.C.L. is an employee of Acuitas Therapeutics, a company focused on the development of lipid nanoparticulate nucleic acid delivery systems for therapeutic applications. P.J.C.L. is named on patents describing the use of modified mRNA lipid nanoparticles."

"We thank Dr. Herman Staats at Duke University for providing us with New Zealand White rabbits and animal handling tips for our study. We also thank Duke Animal Handling Facility for taking care of animals and assistance with immunizations and sample collections. As for the experimental reagents, we appreciate Sanofi Inc. for providing us with post-fusion full-length gB. Also, we appreciate Dr. Ravit Boger from Johns Hopkins University for providing us Toledo virus. We wish to acknowledge following funding sources for supporting this project: (1) Biostatistics, Epidemiology and Research Design (BERD) Methods Core funded through Grant UL1TR002553 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH, to C.C. (2) 5P01AI129859 from the National Institute of Allergy and Infectious Diseases (NIAID), a component of the NIH, to S.R.P. (3) Cancer Prevention and Research Institute of Texas (RP150551 and RP190561) and the Welch Foundation (AU-0042-20030616) to ZA. (4) Medearis CMV Scholar Award from Duke University Medical Center to H.Y.W."