Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite-instable colorectal cancers.

"Conflict of interest statement: ED received endoscopic equipment on loan of Olympus and FujiFilm and research grant from FujiFilm; received honorarium for consultancy from FujiFilm, Tillots, Olympus, GI Supply, Cancer Prevention Pharmaceuticals, PAION and Ambu; and speakers' fees from Olympus, Roche, GI Supply, PAION and IPSEN. BC has several patents pending, which are not relevant to this study. GAM has several patents pending, which are not relevant to this study."

"We thank Roy Reinten, Lisette Hoogendijk, Mireille de Wit, Jitske Grundell‐Weegenaar, and Alex Musler for their technical support in tissue processing and molecular analyses. This work was funded by the Dutch Cancer Society (KWF, grant number 19221). AGCB, JEGIJ, ED and CJMvN designed this study. CJMvN supervised this study. AGCB and JEGIJ carried out the experiments. SvE and CJMvN performed expert pathologic revision. AGCB, JEGIJ, DEFWMvT, and CJMvN collected all required samples and clinical data. PH supervised statistical analyses. DEFWMvT, AGCB and AV carried out all statistical analyses. DEFWMvT, AGCB, JEGIJ, PH, BC, GAM, ED and CJMvN were responsible for data interpretation. DEFWMvT performed all literature searches. DEFWMvT, AGCB, PH and AV designed all figures and tables. DEFWMvT, AGCB and CJMvN wrote the manuscript; all other authors critically revised the manuscript. Funding was acquired by JEGIJ, ED, GAM and CJMvN."