Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9.

"Declarations Ethics approval and consent to participateThis research utilized publicly available summary statistics from published studies and consortia. The original studies included in this analysis have obtained approval from the respective ethical review boards, and all participants have provided informed consent. It is important to note that no individual-level data was utilized in this study. Therefore, no additional ethical review board approval was necessary for this research. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The work was supported by National Natural Science Foundation of China (No. 81873515), Natural Science Foundation of Fujian Province (No. 2020J011072), Innovation Project of Fujian Provincial Health Commission (No. 2021CXA008), and Startup Fund for Scientific Research of Fujian Medical University (No. 2019QH1155)."