ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis.

"availability of data and materials the datasets supporting the conclusions of this article are available in the gepia website http://gepia cancer-pku cn/ the kaplan-meier plotter website https://kmplot com/analysis/ the ucsc xena tcga hub repository https://xenabrowser net/ and the geo repository (code gse45553)."

"Declarations Ethics approval and consent to participateThe acquisition and use of human specimens were in concordance with the International Ethical Guidelines for Research Involving Human Subjects, as stated in the Helsinki Declaration, and were approved by the Medical Ethics Committee of Guangzhou Women and Children’s Medical Center (2022416B01). All the tissue samples were collected after obtaining signed informed consent from the participants. The use of ovarian cancer tissue microarray (TMA) was approved by the Ethics Committee of Shanghai Outdo Biotech Company (SHYJS-CP-1804010). All experiments involving animals were conducted according to the ethical policies and procedures approved by the Southern Medical University Animal Care and Use Committee (L-2020163). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. The authors alone are responsible for the content and writing of this article. Competing interests The authors declare that they have no competing interests. The authors alone are responsible for the content and writing of this article."

"Funding This work was supported by the National Natural Science Foundation of China (82072859 to K.S.), Science and Technology Program of Guangzhou, China (202102010292 to K.S.), and Guangdong Basic and Applied Basic Research Foundation (2022A1515220127 to K.S.)."