A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity.

"Declarations Ethics approval and consent to participateAll authors approved and directly participated in the planning, execution and/or analysis of the data presented here. All protocols were approved by the Ethics Committee of Cancer Hospital of Shantou University Medical College (2022030), and informed consent was obtained from all patients before surgery. All in vivo protocols were approved by the Institutional Animal Care and Use Committee of Shantou University Medical College (SUMC2022-010). Consent for publicationThe content of this manuscript has not been previously published and is not under consideration for publication elsewhere. Competing interestsThe authors declare no conflicts of interest. Competing interests The authors declare no conflicts of interest."

"Funding This work was supported by Natural Science Foundation of Guangdong (2022A1515012529), the National Natural Science Foundation of China (82273404) and Guangdong Medical Science and Technology Research Fund (A2022416, B2022110). Shantou Science and Technology Fund Medical and Health Category (220507126490510, 220506096490279)."