Tolerability and efficacy of the cancer vaccine UV1 in patients with recurrent or metastatic PD-L1 positive head and neck squamous cell carcinoma planned for first-line treatment with pembrolizumab - the randomized phase 2 FOCUS trial.

"Conflict of interest Author AH was employed by the company Clinical Cancer Research Consulting CCRC. AS received research funding from MSD and serves as an advisory board member for MSD. UM-R serves as a consultant or advisor and/or received honoraria from AstraZeneca, BioNTech, BMS, KuraOncology, Merck, MSD, Novartis, and Sanofi. JA serves as an advisor for AstraZeneca, MSD, Novartis, Roche, BMS, Janssen, and Merck and received honoraria from AstraZeneca, BMS, Roche, and Boehringer Ingelheim. KK serves as a consultant or advisor and/or received honoraria from MSD, Merck, BMS, Roche, Novartis, Sanofi, Bayer, BioNTech, Boehringer Ingelheim, and onkowissen. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was funded by the University Hospital Basel."

"Clinical Trial Registration https://clinicaltrials.gov/study/NCT05075122, identifier NCT05075122."