Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma.

"raw data was provided in additional file 16 : table s4"

"Declarations Ethics approval and consent to participateThe present study was performed in accordance with the Declaration of Helsinki. Approval for the use of human subjects was obtained from the research ethics committee of Huashan Hospital, Fudan University (KY2023-594), and informed consent was obtained from each individual enrolled in this study. All animal experiments were approved by the Animal Ethics Committee of Fudan University. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This manuscript was supported by Shanghai Municipal Key Clinical Specialty (No. shslczdzk02004), Shanghai Anticancer Association Chuying Project (SACA-CY22C10), the National Natural Science Foundation of China (No. 81672820 and No. 81930074 and No. 91959203 to L-XQ, 82002532 to L-YY), the Sailing Program of the Shanghai Science and Technology Committee (19YF1405000)."