ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS.

Authors:
Berthiaume AA; Reda SM; Kleist KN; Setti SE; Wu W and 5 more

Journal:
Front Neurosci

Publication Year: 2024

DOI:
10.3389/fnins.2024.1348157

PMCID:
PMC10881713

PMID:
38389786

Journal Information

Full Title: Front Neurosci

Abbreviation: Front Neurosci

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Neurosciences

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
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Evidence found in paper:

"Conflict of interest A-AB, SR, KK, SS, WW, JJ, RT, LS, HM, and KC are employed by and hold stock and/or stock options in Athira Pharma, Inc. A-AB, JJ, RT, and KC are inventors in patent filings related to this work filed by Athira Pharma, Inc."

Evidence found in paper:

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by Athira Pharma, Inc. The funder had the following involvement with the study: study design, analysis, interpretation of data, writing of this article, and the decision to submit for publication."

Protocol Registration
Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025