Spontaneous Breathing Trial Techniques for Extubating Adults and Children Who Are Critically Ill: A Systematic Review and Meta-Analysis.

"In this systematic review and meta-analysis, we conducted a comprehensive search, using database-specific strategies and without language restrictions across several databases, including MEDLINE (from inception to February 2023), the Cochrane Central Register of Controlled Trials (in February 2023), and Embase (from inception to February 2023), to identify potentially eligible trials. Search terms used for article retrieval included are shown in the eAppendix in . We used the optimally sensitive search strategies of the Cochrane Collaboration for both MEDLINE and Embase.,, Eight authors (J.O.F., V.P., V.T., K.L., B.G., K.D., J.C.G.-B., and D.C.) independently screened citation titles and abstracts and subsequently assessed full-text versions of potentially relevant trials. Three authors (V.P., V.T., and J.O.F.) hand searched conference proceedings of 5 scientific meetings from January 1990 to April 2023 where feasible: American Thoracic Society, American College of Chest Physicians (except 1999 to 2002, which was unavailable), International Symposium on Intensive Care and Emergency Medicine, European Society of Intensive Care Medicine, and Society of Critical Care Medicine. Given the nature of the study, no individual patient–level data were used. All data were obtained from published clinical trials. No specific ethics approval was required. A written protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews (CRD42023453264) guided conduct, and the study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline."