ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis.

"Declarations Ethics approval and consent to participateAll animals were in accordance with the guide to the use of Laboratory Animals and were approved by the Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University. Consent for publicationYes. Competing interestsThe authors have no competing interests to declare that are relevant to the content of this article. Competing interests The authors have no competing interests to declare that are relevant to the content of this article."

"Funding This study was funded by the scientific research project for talents introduced by Northwest Minzu University, Grant Number xbmuyjrc2020022 and the Fundamental Research Funds for the Central Universities 31920230001."