The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial.

"Declarations Ethics approval and consent to participate {24}The study obtained ethical approval from the Scientific Ethical Committee (CEC, for its Spanish acronym) at the Faculty of Medicine of Clínica Alemana – Universidad del Desarrollo, accredited by the Regional Service of the Ministry of Health in Chile. Additionally, it is registered with the Office for Human Research Protections of the U.S. Department of Health and Human Services, with an approval date of October 30, 2019. Written, informed consent to participate will be obtained from all participants. Consent for publication {32}Not applicable—no identifying images or other personal or clinical details of participants are presented here or will be presented in reports of the trial results. The participant information materials and informed consent form are available from the corresponding author on request.The consent form is provided in Additional File 1.Competing interests {28}The authors declare that they have no competing interests. Competing interests {28}"

"Funding {4} This trial is funded through the National Fund for Health Research and Development in Health, Chile (FONIS for its acronym in Spanish) of the National Research and Development Agency (ANID), Moneda #1375 Santiago of Chile. The funder’s number for this trial is SA19I0118."

"Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered on 15 September 2023."