Clinical efficacy of metformin in familial adenomatous polyposis and the effect of intestinal flora.

"Declarations Ethics approval and consent to participateThe study was conducted according to the guidelines of the Declaration of Helsinki and approved the Ethics Committee of the 900th Hospital of Joint Logistic Support Force (Lundquist No. 2023-025). All patients provided informed consent before endoscopic examination or intestinal mucosa sampling. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This project was supported in part by the Foreign Cooperation Project of the Department of Science and Technology of Fujian Province (2022I0033), Natural Science Foundation of Fujian Province (2023J011358), and Intra-hospital Project at the 900th Hospital of Joint Logistic Support Force (2020L07)."

"This prospective randomized controlled double-blind trial was conducted at the endoscopy center of the 900th Hospital of Joint Logistic Support Force. Twenty-six patients who attended from January 2022 to July 2022 and met the diagnostic criteria for FAP were included. The clinical diagnostic criteria for FAP required more than 100 adenomas in the general population or more than 20 in patients with a genetic predisposition. The study protocol adhered to the Declaration of Helsinki, and all participants provided written informed consent. The study was approved by the Ethics Committee of the 900th Hospital of the Joint Security Force and registered in the China Clinical Trial Registry (ChiCTR2300071081). All authors had access to the study data and reviewed and approved the final manuscript."