A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.

"overall 4452 transcripts were differentially regulated between induced and uninduced samples of tcreg9 1 rnai clone 3 3 and 5076 transcripts were differentially regulated between induced and uninduced samples of tcreg9 1 rnai clone 4 5 ( fig 4d ; s1 data ).; the depletion of tcreg9 1 by rnai resulted in a reduced kinetoplast repositioning in each case in the absence of cis aconitate (tif) s1 table individual transcripts are colour coded according to their encoded protein family (tif) s2 table (xlsx) s1 data individual sheets provide values for distinct rnai clones (clone 3 3; clone 4 5) and include expression values for all genes or where the logfc change is >1 or <-1 (upregulated genes or downregulated genes). s2 table (xlsx data availability gene expression data is available in the geo database. the geo accession number for the rna seq sequence data is gse249623"

"The authors have declared that no competing interests exist."

"This work is supported by a Wellcome Trust investigator award (Wellcome Trust, https://wellcome.org; grant number 221717/Z/20/Z to KM), a NC3Rs (https://nc3rs.org.uk) Research Grant (NC/W001144/1 to CG); a BBSRC (https://www.ukri.org/councils/bbsrc/) Research Grant (BB/W005867/1 to CG) and BBSRC (https://www.ukri.org/councils/bbsrc/) Research Grant (BB/W000342/1 to BW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."