Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial.

"Declarations Ethics approval and consent to participateThis single-center, randomized, controlled study obtained approval and registration from the Chinese Clinical Trial Registry (registration no. ChiCTR2200066642, chictr.org.cn, 12/12/2022) and was reviewed by the Ethics Committee of Renmin Hospital (syrmyy2022-80), and conducted following the Declaration of Helsinki. Written informed consent was acquired from all participating patients or their legal representatives. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The study was supported by National Natural Science Foundation of China:(81701891); Hubei province Science and technology Department key research and development plan(Grant No.2022BCE007)."