EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer.

"Declarations Ethical approval and consent to participateThe Medical Ethics Committee of the First Affiliated Hospital of Guangxi Medical University has approved all experimental protocols (2023-E089-01). All experiments were performed in accordance with ARRIVE guidelines and regulations. All methods were performed in accordance with ARRIVE guidelines for reporting animal experiments. Consent for publicationNot applicable. Conflict of interestThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Funding This study was supported by the National Natural Science Foundation of China (81960439) and the cultivation project of the characteristic innovation team of the First Affiliated Hospital of Guangxi Medical University (YYZS2020007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."