The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.

"r codes used for the multivariate latent class regression are provided in the supplementary file. r codes used for the multivariate latent class regression are provided in the supplementary file."

"Declarations Ethics approval and consent to participateThe samples were collected with the written informed consent of all participants. ADNI studies follow Good Clinical Practices guidelines, the declaration of Helsinki and United States regulations (U.S. 21 CFR Part 50 and part 56). ADNI studies were approved by all the respective Institutional Review Boards of academic institutions involved in the consortium. For our specific study, we received approval from the Duke University Health System Institutional Review Board under the Protocol IDs Pro00109279 and Pro00105389. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG076019, R01AG070487. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."