First report of a p.Cys484Tyr Notch3 mutation in a CADASIL patient with acute bilateral multiple subcortical infarcts-case report and brief review.

"Declarations Ethics approval and consent to participatewe confirm that informed consent was obtained from all subjects and their legal guardians.The consent was for publication of all patients’ of potentially identifying personal and medical information including any associated images. The studies involving human participants were reviewed and approved by the Medical Research Ethics Committee at Affiliated Hospital of Weifang Medical University(No.wyfy-2023-qt-095).We confirm that all experiments were performed in accordance with relevant guidelines and regulations ( the Declaration of Helsinki). Consent for publicationThe written informed consent was obtained from all subjects and their legal guardians. The consent was for publication of all patients’ of potentially identifying personal and medical information including any associated images. A copy of the written consent is available for review by the editor upon request. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The present study was supported by the Yuan Du Scholars, Clinical Research Center of Affiliated Hospital of Weifang Medical University (grant no. 2022WYFYLCYJ02) and Weifang Science and Technology Development Plan Project Medical category (grant no. 2022YX093)."