Differential contribution of THIK-1 K⁺ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia.

"Declarations Ethics approval and consent to participateAll procedures involving the handling of living animals were performed in accordance with German animal protection law and were approved by the local authorities for health and social services (LaGeSo T 0045/15). All human tissue samples were collected from donors for whom full written consent was obtained for use of material and clinical information in accordance with the World Medical Associations Declaration of Helsinki for Medical Research. Experimental procedures adhered to ethical requirements and were approved by the local ethical committee with licence number EA2/111/14. Competing interestsBO, RB, LD, NB, AW, ML, XX, KP were employers of Cerevance Ltd at the time their contribution to this work. AR and CM were supported by Cerevance Ltd for part of this work. Competing interests BO, RB, LD, NB, AW, ML, XX, KP were employers of Cerevance Ltd at the time their contribution to this work. AR and CM were supported by Cerevance Ltd for part of this work."

"Funding Open Access funding enabled and organized by Projekt DEAL. This work was supported in parts by grants from the German Research Foundation (SFB/TRR 167 A10N) and the Alzheimer Forschung Initiative (21072) to CM, and scholarships from the Sonnenfeld Stiftung and the Berlin Institute of Health (BIH) to AR. We also thank the Advanced Medical BioImaging Core Facility of the Charité-Universitätsmedizin Berlin (AMBIO) for support in acquisition of the imaging data. Illustrations were created with Biorender.com."